Strong
SkincareTretinoin
A prescription topical retinoid with strong evidence for improving visible signs of sun-damaged skin.
ANABIOTICASubmit a source Independent longevity index · v0.1
Live longer.Know what works.
A clear, evidence-ranked library of skincare, supplements, nootropics, weight management, peptides, lifestyle, and the science shaping healthy longevity.
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The longevity library
Strong
SkincareBroad-Spectrum SPF
Daily broad-spectrum sunscreen has randomized evidence for slowing visible photoaging while reducing ultraviolet exposure.
Strong
SupplementsCreatine Monohydrate
A well-studied supplement for high-intensity performance, muscle, and strength, including during resistance training in older adults.
Strong
Weight lossSemaglutide
A prescription GLP-1 medicine with strong trial evidence for substantial weight loss in eligible adults when combined with lifestyle support.
Strong
Weight lossTirzepatide
A prescription GIP/GLP-1 medicine that produced substantial, sustained weight loss in a large phase 3 obesity trial.
Strong
SupplementsPsyllium Husk
A soluble viscous fiber with replicated evidence for lowering LDL cholesterol and improving chronic constipation when taken with enough fluid.
Strong
PeptidesTesamorelin
An approved growth-hormone-releasing peptide that reduces visceral fat in HIV-associated lipodystrophy but is not a general weight-loss or anti-aging treatment.
Strong
Weight lossMetabolic and Bariatric Surgery
The most durable established treatment for severe obesity, with large weight and metabolic benefits alongside procedure-specific lifelong risks and follow-up.
Strong
LifestyleAerobic Physical Activity
Regular walking and other aerobic activity preserve mobility and cardiometabolic health, with the largest practical gain coming from moving out of inactivity.
Strong
LifestyleResistance Training
Progressive strength training reliably improves muscle strength and physical function across age, including in very old and frail adults.
Strong
LifestyleSmoking Cessation
Stopping smoking improves health at any age, with unusually strong mortality evidence and effective combinations of behavioral and medication support.
Strong
SupplementsProtein Supplementation
A practical way to close a dietary protein gap, with the clearest muscle benefit when paired with resistance training rather than used alone.
Strong
SupplementsPlant Sterols and Stanols
Food-derived compounds that reliably lower LDL cholesterol when consumed in fortified foods, without direct evidence that supplements prevent heart attacks or extend life.
Strong
NootropicsCaffeine
A well-studied stimulant that reliably improves alertness and attention, with sleep disruption and tolerance as the main tradeoffs.
Strong
Weight lossLiraglutide
A daily GLP-1 receptor agonist with strong obesity-trial evidence for clinically meaningful weight loss, balanced against gastrointestinal effects, cost, and regain after stopping.
Strong
Weight lossOrlistat
An oral intestinal lipase inhibitor that produces modest, durable weight loss but commonly causes meal-dependent gastrointestinal effects.
Strong
Weight lossPhentermine + Topiramate
An effective once-daily oral obesity medicine whose weight-loss benefit must be balanced against pregnancy, cognitive, mood, and cardiovascular precautions.
Strong
Weight lossIntensive Lifestyle Intervention
A high-contact program of calorie reduction, physical activity, behavioral skills, and long-term support that can sustain meaningful weight loss without guaranteeing cardiovascular-event reduction.
Strong
LifestyleDASH Eating Pattern
A flexible eating pattern rich in fruits, vegetables, legumes, whole grains, and low-fat dairy with strong evidence for lowering blood pressure.
Strong
LifestyleCognitive Behavioral Therapy for Insomnia
A structured, first-line insomnia treatment that produces durable improvements in sleep without relying on nightly sedative medication.
Strong
SkincareAdapalene
A topical retinoid with strong acne evidence and smaller off-label evidence for photoaging.
Moderate
SkincareNiacinamide
A well-tolerated vitamin B3 derivative with controlled human evidence for modest improvements in visible photoaging, pigmentation, and skin-barrier function.
Moderate
SupplementsOmega-3s
Routine fish-oil supplements do not clearly prevent major cardiovascular events, while selected prescription formulations have narrower evidence and different risks.
Moderate
LifestyleMediterranean-Style Eating
A flexible food pattern with randomized evidence for fewer cardiovascular events in high-risk adults, tempered by influential-trial limitations and variable definitions.
Moderate
SkincareRetinol
An over-the-counter vitamin A derivative with controlled human evidence for modest wrinkle improvement, but less standardization than prescription tretinoin.
Moderate
SupplementsVitamin D
Essential for calcium and bone biology and useful for treating deficiency, but routine supplementation has not delivered broad longevity benefits in generally healthy adults.
Moderate
LifestyleTai Chi
A low-impact mind-body exercise with credible evidence for improving balance and reducing falls in older adults, but no direct longevity proof.
Moderate
ResearchCaloric Restriction
Sustained energy reduction without malnutrition that improves several cardiometabolic markers in non-obese adults but has not been shown to extend human lifespan.
Moderate
LifestyleKetogenic Diet
A very-low-carbohydrate, high-fat eating pattern with an established specialist role in drug-resistant epilepsy and mixed, mostly short-term evidence for weight and metabolic outcomes.
Moderate
SkincareHyaluronic Acid
A generally well-tolerated topical humectant that reliably improves surface hydration, with smaller and more formulation-specific evidence for temporary smoothing of fine lines.
Moderate
SkincareAzelaic Acid
A topical dicarboxylic acid with useful evidence for acne, papulopustular rosacea, and some hyperpigmentation disorders.
Moderate
SkincareCeramide Moisturizers
Barrier-supporting moisturizers that help dry and eczema-prone skin, without clear proof that ceramides outperform every simpler emollient.
Moderate
SkincareUrea
A concentration-dependent moisturizer and keratolytic with useful evidence for dry, thickened, and scaly skin.
Moderate
SupplementsMagnesium
An essential mineral where correcting deficiency is important, while extra supplementation offers narrower, indication-specific benefits.
Moderate
SupplementsZinc
An essential trace mineral where deficiency correction matters and oral lozenges may shorten a cold, but excess use can create copper deficiency and neurologic harm.
Moderate
SupplementsProbiotics
Live microorganisms whose effects are strain- and indication-specific, with the clearest signal in preventing some antibiotic-associated diarrhea.
Moderate
NootropicsMelatonin
A circadian-timing hormone useful for jet lag and selected sleep-timing problems, with only small average effects in chronic insomnia.
Moderate
Weight lossNaltrexone + Bupropion
An oral prescription combination that produces modest average weight loss but has important opioid, seizure, blood-pressure, and psychiatric precautions.
Moderate
Weight lossSetmelanotide
A daily MC4-receptor agonist for specific rare genetic and acquired hypothalamic obesity—not a general obesity drug.
Emerging
PeptidesCollagen Peptides
Oral hydrolyzed collagen may modestly improve skin hydration or elasticity, but study quality and industry funding temper confidence.
Emerging
SupplementsGlyNAC
A glycine and N-acetylcysteine combination with promising but preliminary human data on glutathione and aging-related markers.
Emerging
NootropicsCaffeine + L-Theanine
A tea-derived pairing with evidence for small, short-term attention benefits in controlled laboratory tasks.
Emerging
NootropicsBacopa Monnieri
A traditional herbal extract with inconsistent modern evidence for memory and attention and meaningful variation between products.
Emerging
SkincareVitamin C
Some formulations may modestly improve pigmentation and visible photoaging, but a small heterogeneous evidence base and unstable chemistry make products hard to compare.
Emerging
NootropicsModafinil
A prescription wakefulness medicine with only a very small average cognitive effect in rested healthy adults and important medical, interaction, and sporting constraints.
Emerging
NootropicsLion's Mane
A popular medicinal mushroom with intriguing preclinical biology but mixed, tiny, and product-specific human cognition studies.
Emerging
Weight lossRetatrutide
An investigational triple-hormone-receptor agonist with unusually large phase 2 weight-loss results and promising but not yet peer-reviewed phase 3 toplines.
Emerging
PeptidesGHK-Cu
A copper-binding peptide with plausible skin and wound biology but sparse controlled human evidence and no established role for injectable anti-aging use.
Emerging
ResearchNAD+ Precursors
Nicotinamide riboside and NMN reliably alter NAD-related biomarkers, but human trials have not established broad improvements in function, disease prevention, or longevity.
Emerging
ResearchAcarbose for Longevity
A prescription carbohydrate-absorption drug that extends lifespan in mice and delays diabetes in some high-risk humans, without evidence that it extends human life.
Emerging
ResearchTaurine for Longevity
An amino-sulfonic acid with striking animal-aging results and modest cardiometabolic trial signals, but conflicting human biomarker data and no lifespan evidence.
Emerging
SupplementsOPC (Grape Seed Extract)
A proanthocyanidin-rich botanical extract with small, inconsistent effects on blood pressure and lipid markers, but no demonstrated protection from cardiovascular events or aging.
Emerging
SkincareGlycolic Acid
An alpha-hydroxy acid that can improve texture and discoloration, with effects and risks that rise sharply from home products to chemical peels.
Emerging
SkincareRed Light Therapy
Nonthermal red and near-infrared light with promising small trials for visible photoaging, but major device and dosing uncertainty.
Emerging
SupplementsCoenzyme Q10
A mitochondrial cofactor with a possible adjunctive role in heart failure, but inconsistent evidence for common wellness and statin-muscle claims.
Emerging
SupplementsBerberine
A plant alkaloid with short-term glucose and lipid signals, limited by uneven trial quality, gastrointestinal effects, and broad interaction potential.
Emerging
SupplementsCurcumin (Turmeric Extract)
A variable botanical supplement with possible short-term knee-osteoarthritis symptom relief and a rare but real liver-injury signal.
Emerging
SupplementsBeetroot (Dietary Nitrate)
A nitrate-rich food concentrate with small exercise and blood-pressure effects that vary by fitness, dose, product, and testing conditions.
Emerging
NootropicsAshwagandha
A traditional botanical with small short-term stress and sleep trials, substantial product variation, and uncommon liver and thyroid risks.
Experimental
ResearchRapamycin
An mTOR inhibitor with compelling animal longevity data but no established anti-aging benefit in healthy humans.
Experimental
ResearchSenolytics
Experimental compounds intended to remove senescent cells, with intriguing biology but only tiny early human studies.
Experimental
ResearchMetformin
A foundational diabetes medicine and prominent geroscience candidate whose observational longevity signals have not become proof of slower aging in healthy people.
Experimental
ResearchPartial Cellular Reprogramming
A frontier gene-therapy strategy that can reset selected aging signals in animals and has only just entered localized first-in-human safety testing.
Experimental
ResearchResveratrol
A heavily studied polyphenol with compelling laboratory biology but no clinical proof of slower human aging or longer life.
Experimental
ResearchSpermidine
A dietary polyamine linked to autophagy in laboratory models, with early human trials that have not established cognitive, anti-aging, or longevity benefits.
Insufficient
PeptidesBPC-157
An unapproved research peptide promoted for healing despite an evidence base dominated by animal studies and unresolved safety questions.
Insufficient
PeptidesCJC-1295 + Ipamorelin
A marketed growth-hormone peptide stack with no controlled combination trial, ambiguous product identity, and major compounded-injection evidence gaps.
Insufficient
NootropicsGinkgo Biloba
A widely marketed botanical that has not prevented dementia or slowed normal cognitive decline in large, rigorous trials.
Insufficient
PeptidesHuman Growth Hormone
A prescription hormone with established replacement indications but an unfavorable benefit-risk profile for healthy-aging or physique use.
Insufficient
ResearchYoung-Donor Plasma
An unapproved anti-aging intervention extrapolated from animal parabiosis, with no demonstrated clinical benefit and real transfusion-related risks.
Insufficient
SupplementsGlucosamine + Chondroitin
Popular osteoarthritis supplements with inconsistent symptom and joint-structure results that depend partly on formulation and study quality.
Research pulse · 04
What the science is saying now.
Short, plain-language reads on the studies worth paying attention to.
Read the latest notesCan we measure biological age well enough to act on it?
Where epigenetic clocks help, where they mislead, and what a useful marker needs to do.
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