ANABIOTICASubmit a source Supplements.
Supplement evidence depends on the nutrient, dose, formulation, baseline status, and intended outcome. Correcting a deficiency or treating a defined condition is different from taking more of the same ingredient for general longevity.
16 evidence-ranked entriesWhat the evidence cannot settle yet
Short trials often measure biomarkers rather than disease, function, or lifespan. Product composition varies, and findings from a prescription formulation, standardized extract, or deficient population may not transfer to a retail supplement used by a generally healthy adult.
Risks depend on the intervention
Dose-related gastrointestinal effects and medicine interactions are common themes. Kidney or liver disease, pregnancy, anticoagulants, and variable product quality can turn an apparently routine supplement into a higher-risk decision.
Strong evidence leads this category
Ratings compare confidence in each entry's stated benefit—not whether every intervention is appropriate or recommended.
How ratings workEvery supplements entry
Sorted from stronger to weaker evidence.
Creatine Monohydrate
A well-studied supplement for high-intensity performance, muscle, and strength, including during resistance training in older adults.
Psyllium Husk
A soluble viscous fiber with replicated evidence for lowering LDL cholesterol and improving chronic constipation when taken with enough fluid.
Protein Supplementation
A practical way to close a dietary protein gap, with the clearest muscle benefit when paired with resistance training rather than used alone.
Plant Sterols and Stanols
Food-derived compounds that reliably lower LDL cholesterol when consumed in fortified foods, without direct evidence that supplements prevent heart attacks or extend life.
Omega-3s
Routine fish-oil supplements do not clearly prevent major cardiovascular events, while selected prescription formulations have narrower evidence and different risks.
Vitamin D
Essential for calcium and bone biology and useful for treating deficiency, but routine supplementation has not delivered broad longevity benefits in generally healthy adults.
Magnesium
An essential mineral where correcting deficiency is important, while extra supplementation offers narrower, indication-specific benefits.
Zinc
An essential trace mineral where deficiency correction matters and oral lozenges may shorten a cold, but excess use can create copper deficiency and neurologic harm.
Probiotics
Live microorganisms whose effects are strain- and indication-specific, with the clearest signal in preventing some antibiotic-associated diarrhea.
GlyNAC
A glycine and N-acetylcysteine combination with promising but preliminary human data on glutathione and aging-related markers.
OPC (Grape Seed Extract)
A proanthocyanidin-rich botanical extract with small, inconsistent effects on blood pressure and lipid markers, but no demonstrated protection from cardiovascular events or aging.
Coenzyme Q10
A mitochondrial cofactor with a possible adjunctive role in heart failure, but inconsistent evidence for common wellness and statin-muscle claims.
Berberine
A plant alkaloid with short-term glucose and lipid signals, limited by uneven trial quality, gastrointestinal effects, and broad interaction potential.
Curcumin (Turmeric Extract)
A variable botanical supplement with possible short-term knee-osteoarthritis symptom relief and a rare but real liver-injury signal.
Beetroot (Dietary Nitrate)
A nitrate-rich food concentrate with small exercise and blood-pressure effects that vary by fitness, dose, product, and testing conditions.
Glucosamine + Chondroitin
Popular osteoarthritis supplements with inconsistent symptom and joint-structure results that depend partly on formulation and study quality.